Julius Brennecke , in Transposon Silencing An Epigenetic Role for Maternally Inherited piRNAs
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An epigenetic role for maternally inherited piRNAs in transposon silencing.
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Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. In Drosophila, piRNAs are encoded by heterochromatic clusters and maternally deposited in the embryo. Paternally inherited P element transposons thus escape silencing and trigger...
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